IMEDEEN Prime Renewal^TM - CLINICAL AND SCIENTIFIC STUDIES

• Improve dermal density
• Improve laxity and sagging
• Reduce visibility of fine lines and wrinkles
• Reduce visibility of hyperpigmentation
• Improve the appearance of skin on hands and décolletage

66% of the women interviewed who experienced positive results said that their friends and family had also commented on the improvements to their skin.

“My skin is softer, smoother and the dark circles under my eyes have improved. My sister noticed. I would recommend them – I could see an improvement which surprises me with anything nowadays.”.

DOCUMENTED RESULTS:
Abstract and oral presentation:Effect of a novel dietary supplement on skin-aging in postmenopausal women. Anti-aging World Congress 10-12 March 2005, Monaco

SCIENTIFIC STUDY ON IMEDEEN PRIME RENEWAL – DR NICO SMIT AND DR STAN PAVEL – LEIDEN UNIVERSITY MEDICAL CENTRE, THE NETHERLANDS

An in-vitro study was carried out on the ViTea® protection complex to assess the increased defence against free radical damage. Skin fibroblasts were cultured under standard conditions. One culture was treated with the ViTea® Complex, the other was used as a control. Both cultures were irradiated in parallel with UV light. Multiple methods were used to analyse the extent of oxidative damage on the skin cells and measure the production of free radicals in both cultures.

The results show that the ViTea® complex minimises the amount of UV damage in skin cells. It decreases the amount of free radicals produced in skin fibroblasts and reduces the damage caused by UV radiation in essential building blocks such as lipids and DNA.

DOCUMENTED RESULTS:
Poster presentation: Cellular protection by natural antioxidants in cultured human skin cells. 11th Annual Meeting of the Society for Free Radical Biology & Medicine, November 17-21, 2004 US Virgin Islands, St. Thomas.

Abstract from the 11th Annual Meeting of the Society for Free Radical Biology & Medicine (above) was published in international scientific journal: Nico Smit, Fred Romijn, Ali Vahidnia, Stan Pavel and Hans van Pelt and Jana Vicanova. Cellular protection by natural antioxidants in cultured human skin cells. Abstract. Free Radical Biology & Medicine 37: Supplement 1, S43, 2004.

SCIENTIFIC STUDY ON IMEDEEN PRIME RENEWAL – DR ODILE DAMOUR – LABORATORY FOR SKIN SUBSTITUTES, LYON, FRANCE

An in-vitro study was carried out to measure the effects on the dermal and epidermal structure using fully developed skin equivalents generated from skin fibroblasts volunteered by a 19 year old girl and 49 year old post-menopausal woman. The skin equivalents were treated with the Imedeen Prime Renewal active ingredients and a control group was cultured in parallel without treatment.

Although both the young and the old skin equivalents showed that treatment with Imedeen Prime Renewal improved the quality and structure of both the dermis and epidermis versus the control cultures, the results for the aged skin equivalent were much more impressive than those for the young skin and showed a greater increase in dermal density, higher production levels of both collagen and elastin and an improved epidermal structure. Moreover treatment with Imedeen Prime Renewal prolonged the life span of both young and aged skin equivalents, clearly demonstrating the anti-ageing effect of the active ingredients.

DOCUMENTED RESULTS: Poster presentations and abstracts:
Efficiency test of an oral cosmetic “Imedeen Prime Renewal” using a 3-D skin equivalent model. Sophie Lacroix, Sandrine Vidal, Charbel Bouez ,Valérie Cenizo, Virginie Justin, Jana Vicanova, Pascal Sommer and Odile Damour.
Congess of Societe de Pharmaco-Toxicologie Cellulaire, Sept 20-21, 2004. Paris.

Effect of ’Imedeen prime renewal’ on dermal matrix and epidermal proliferation using skin equivalent model. Sophie Lacroix, Sandrine Vidal, Charbel Bouez, Valérie Cenizo, Virginie Justin, Jana Vicanova, Pascal Sommer and Odile Damour. 3rd international symposium of the science and technology of Skin engineering, 14-15.